|
Science
Friday > Archives
> 1998
> January
> January 16, 1998:
Hour One: Aging Update / Genes For Forgetfulness
In September, we told you about researchers that had located the genes
for telomerase, a protein that might help cells live longer. Now, related
research from the University of Texas Southwestern Medical Center and
the Geron Corporation have confirmed that the presence of telomerase
actually does make ordinary cells live longer. Their work may offer
new ways to help cells live longer - or, alternately, to make long-lived
cancer cells start to die.
|
The telomere is a cap of repeating genes at the
tip of the chromosome. Every time the cell divides,
the chromosome is duplicated - and its telomeres
get shorter. The number of times a cell can divide
is determined by its chromosomes' telomere length;
when the telomere becomes too short the cell can no
longer divide. Some specialized cells, like sperm
cells, must divide more times than their telomeres
might allow. These cells produce telomerase, a
compound that rebuilds their telomeres. Cancer
cells also often produce telomerase, which makes
them "immortal."
|

The chromosomes are x-shaped
bundles of
genetic material in the cell nucleus.
At the end of each chromosome is a cap called a
telomere, like the plastic tip on a
shoelace.
|

Telomerase repairs
the tips
of chromosomes, allowing
cells to keep dividing and
live longer.
|
In the current study, researchers added
telomerase to human cells that do not usually
produce it. They found that the cells containing
telomerase were able to divide up to 20 times more
than the non-telomerase containing cells. The
researchers are now looking into possible uses for
their findings, from treatment of some of the
diseases of aging to producing better cell samples
for use in the lab. The team has also been looking,
without success, for possible ways to block
telomerase production in cancer cells.
On this segment of Science Friday, we'll take a
look at the team's findings, and see what
implications they could have for the world of
medicine.
|
Then...forgetfulness. People have known for quite a while about genes
that help to suppress tumors, keeping cancerous cells in check. Now,
however, researchers say that there may be genes that suppress memories
as well -- and these genes aren't all bad.
|
Memory suppressor genes, argue the team from the Howard Hughes
Medical Institute at Columbia University, aid in regulating long-term
memory storage. They allow you to remember important details,
like what your car looks like, but forget less important details
- like the license plate numbers of the thirty other cars parked
nearby. Memory suppressor genes may also help to clear out the
cobwebs in the synapses prior to learning new material.
|
|
On this segment of Science Friday, we'll take a look at current findings
in memory research - don't forget to tune in.
Guests:
Michael Fossel
Author,
"Reversing
Human Aging"
Clinical Professor of Medicine
Michigan State
University
East Lansing, MI
Calvin Harley
Chief Scientific Officer
Geron Corporation
Menlo Park, CA
Kelsey Martin
Post-doctoral Fellow
Howard Hughes Medical Institute
Center for Neurobiology and Behavior
Columbia University
New York, NY
Dusan Bartsch
Post-doctoral Fellow
Howard Hughes Medical Institute
Center for Neurobiology and Behavior
Columbia University
New York, NY
Books/Articles Discussed:
Related Links:
Our
September 5, 1997 show on the biology of aging
The
Telomere Club
Telomere
Info from TelDB
Geron Corporation
The National Institute
on Aging
The Administration on
Aging
The Aging Research
Centre
GeroWeb
American Psychological Association
American Psychological Society
Memory Disorders Research
Society
SARMAC - the
Society for Applied Research in Memory and Cognition
|