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Science Friday > Archives > 1998 > May > May 1, 1998:

Hour One:
Edible Vaccines / Missing Energy

This week, researchers announced that they had shown for the first time that an edible vaccine can set off immune responses in people. Though there is still much more work to be done before doctors can throw away their needles, the report, published in the May issue of Nature Medicine, raises hopes that a new method for dealing with large-scale vaccinations may be practical.

The scientists, from the University of Maryland in Baltimore, Tulane University in New Orleans, and the Boyce Thompson Institute for Plant Research in Ithaca, fed volunteers slices of genetically-engineered potato that were bred to produce proteins from a diahhrea-causing bacterium. After eating three doses of potato over a period of three weeks, volunteers had antibodies to the bacterium in both their intestines and in their blood serum. However, the presence of these antibodies does not guarantee immunity to the bacterium, the researchers said.

Edible vaccines are seen by many to be a key part of developing workable vaccination programs for many of the world's developing nations. The cost of storing and distributing vaccines accounts for a large part of their expense - a plant-based delivery system, in which genetically engineered seed could be distributed, then planted and harvested to yield working vaccines, would make vaccines accessible to more areas of the world. In addition, of course, edible vaccines have the advantage of not requiring the painful needle-stick of injected vaccines.

The potato-based vaccines currently under study must be eaten raw - but other plants under consideration include banana and tomato, much tastier in uncooked form. Scientists are looking to edible vaccines to help fight diseases from diahhrea to cholera to hepatitis B.

Then...In early March, two teams of astronomers announced that they had found that the universe was expanding at an ever-increasing rate - instead of gradually slowing to a halt, reined in by the pull of gravity. (Check out SciFri's coverage of the announcement - web page | RealAudio recording) This weekend, astrophysicists from across the country are gathering at the Fermi National Accelerator Laboratory (Fermilab) in Illinois to discuss the findings and what they mean.

Some propose that Einstein's "cosmological constant" may actually exist, and point to a type of energy that comes from a vacuum as the source of the constant's push. Others use theories involving superstrings or exotic particles like pions and bosons to explain the push and pull of the universe.

In other astronomical mystery news, this week a team of astronomers from the University of Alabama in Huntsville, University College in London, and the National Radio Astronomy Observatory in Green Bank, WV announced that they may have discovered the long-sought after "missing matter" that provides the gravitational glue keeping galactic clusters from flying apart. Using NASA's Extreme Ultraviolet Explorer satellite, the team detected a faint glow coming for something in between the galaxies. The glow, they theorize, may be the ultraviolet signature of a very dilute cloud of gas spread throughout interstellar space. Although the cloud is very thin - on Earth it would be better than the best vacuum available - when added up over trillions of cubic light years, the cloud could weigh more than the stars in hundreds of galaxies. That extra mass, the team concludes, would provide enough extra matter to balance the equation.

coma cluster
A section of the Coma galaxy cluster.
(click for larger view)
(image rotated 90 degrees clockwise )
(credit: W. Baum, Hubble WFPC Team and STSCI)

Abell 2218 with grav. lensing
Galaxy cluster Abell 2218. The image looks bent because of the intense gravitational field around the cluster. (click for larger view)
(credit: W. Couch, R. Ellis and NASA)


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Guests:
Charles Arntzen
President and CEO
Boyce Thompson Institute for Plant Research Inc
Ithaca, NY

Mary Lou Clements-Mann
Professor
Johns Hopkins University School of Public Health
Baltimore, MD

Michael Turner
Scientist 2
Fermi National Accelerator Laboratory
Professor and Chairman of the Department of Astronomy and Astrophysics
University of Chicago
Chicago, IL

Books/Articles Discussed:

A book reccommended by our guest : "Shadows of Creation" by Michael Riordan, David Schramm, and Stephen Hawking

(find more SciFri Books here)

Search for books on:

Related Links:

Some information about edible vaccines
From the NIH
From Science News
From Texas A&M

Boyce Thompson Institute for Plant Research
Tulane University School of Medicine

Cosmological Constant info
An Introduction to Cosmology (NASA MAP project)
Cosmology Tutorial (Ned Wright, UCLA)

Cosmology Resources (Net Advance of Physics)
Fermilab

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