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Science Friday > Archives > 2000 > July > July 28, 2000: 

Hour One: Schizophrenia

The National Institute of Mental Health estimates that over two million Americans are affected by schizophrenia in any given year. It's a very complex condition, made up of so many different aspects that it is sometimes difficult to diagnose -- and even more difficult to treat.

There is no known single cause of schizophrenia. Recent research indicates that there may be a genetic component, accounting for the fact that schizophrenia often tends to run in families -- but no single gene has been identified as the source of the condition. Scientists generally agree that a tendency towards schizophrenia can be inherited, but that environmental factors also play a part.

There are a number of different treatments and treatment combinations available for people with schizophrenia, though none offers a complete cure. Antipsychotic drugs allow people with schizophrenia to function more appropriately, without suffering from extreme delusions. Various forms of psychotherapy may also be used to help people acknowledge their condition and deal with it effectively. However, the medications involved often carry unpleasant side effects. Keeping people with schizophrenia on medication voluntarily can sometimes be a difficult process.

Some scientists are studying whether giving anti-psychotic drugs to teenagers deemed at risk for developing schizophrenia could actually prevent the disease--a controversial approach because it's so tough to determine who's at risk. In this hour, we'll discuss the causes of schizophrenia, including the role of genetics and a theory that viruses trigger the illness.


PET imaging showing areas of brain activity in twins - one schizophrenic, one not. (image courtesy Dr. Karen Berman, Clinical Brain Disorders Branch, NIMH, NIH)

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Guests:
Robert Conley, M.D.
Associate Professor, Department of Psychiatry
University of Maryland School of Medicine
Baltimore, Maryland

Ann Pulver , Sc.D.
Chief, Epimediology-Genetics Program in Psychiatry
Associate Professor, Psychiatry and Behavioral Sciences
Johns Hopkins University School of Medicine
Baltimore, Maryland

Robert Yolken, M.D.
Director, Stanley Neurovirology Laboratory
Ted and Vada Stanley Professor of Developmental Neurovirology
Department of Pediatrics
Johns Hopkins University School of Medicine
Baltimore, Maryland

Books/Articles Discussed:

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Related Links: 

What is Schizophrenia?
Schizophrenia.com, The Schizophrenia Home Page
Schizophrenia Knowledge Center
NIMH - Schizophrenia-Related Gene Site Reported
National Alliance for the Mentally Ill
National Mental Health Association
Schizophrenia Q&A from the National Institute of Mental Health
American Psychiatric Association: What is Schizophrenia
Mentalhealth.com

Produced By: Karin Vergoth
Web Producer: Charles Bergquist

 

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