What Makes Stem Cells Stem Cells?

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02/22/2008

Feb. 22, 2008

What Makes Stem Cells Stem Cells?

In the past few years, scientists have drawn several parallels between stem cells and cancer cells. In tumor formation, formerly specialized tissue cells somehow become 'reprogrammed' to form tumor tissue. A similar reprogramming takes place in the creation of stem cells. Both types of cells also have an unusual ability to renew themselves. So what is it that lets a stem cell know it's a stem cell, and not a cancer cell?

In this segment, Joe Palca talks with stem cell researcher George Daley about the discovery of a protein that may help give stem cells their unusual multi-function abilities. The protein, named Lin-28, appears to help regulate the activity of certain small RNA molecules called “let-7 microRNAs” found in both stem cells and cancer.

Produced by Charles Bergquist, Director and Contributing Producer

Guests

George Q. Daley
Associate Professor of Biological Chemistry
and Molecular Pharmacology

Harvard Medical School

Associate Professor of Pediatrics

Children's Hospital Boston

Boston, Massachusett

Feb. 22, 2008