02/26/2021

Progress In Considering Sex As A Biological Variable

9:07 minutes

Back in 2013, Charles Hoeffer from the University of Colorado Boulder was studying memory and learning in mice. He was looking at a specific protein in the brain called AKT1, which helps mice forget an old task and learn a new one. In humans, a mutation in that protein has been linked to disorders like schizophrenia, Alzheimer’s and depression.

But in a follow-up study, Hoeffer did something different. He included both male mice and female mice, and then tested them separately. As expected, he discovered that male mice had a much tougher time learning the task when AKT1 wasn’t working. But in female mice, he found the unexpected: It didn’t make any difference whether the protein was removed or not. In other words, the sex of the mouse became an important variable that affected the outcome of the research.

Hoeffer’s study is one example of considering sex as a biological variable (SABV) in pre-clinical research. And in 2016, the National Institutes of Health’s Office of Research on Women’s Health made it an official policy for researchers applying for funding. 

But that didn’t change things overnight. Five years later, the approach is still catching on in many areas of research. Chyren Hunter, from the Office of Research on Women’s Health, joins Ira to discuss the progress that’s been made, and what lies ahead for the effort to make pre-clinical research more inclusive.

Further information on the NIH’s policy on sex as a biological variable is on its website.


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Segment Guests

Chyren Hunter

Chyren Hunter is associate director for basic and translational research in the Office of Research on Women’s Health at the National Institutes of Health, in Bethesda, Maryland.

Charles Hoeffer
Charles Hoeffer is an assistant professor of integrated physiology at the Institute for Behavioral Genetics at the University of Colorado Boulder.

Segment Transcript

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