Last week, biographer and journalist Walter Isaacson delivered the 43rd annual Jefferson Lecture—the government’s highest honor for people working in the humanities. But Isaacson’s message wasn’t just for humanists. He argued that the future belongs to those who can appreciate both the arts and the sciences. Isaacson joins Ira to explain how thinkers from Einstein to Steve Jobs drew on both spheres to make their breakthroughs, and why mixing the two is more important than ever in the digital age.