02/20/26

Why Aren’t There Biomarkers For Mental Illness?

Despite major advances in our understanding of the biology of mental health disorders,  there’s no blood test or brain scan that will confirm if you have depression, anxiety, PTSD, or any other psychiatric illness. 

And yet, the American Psychiatric Association recently announced that it will be including biomarkers for mental conditions in the next edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM), which guides diagnosis and treatment of mental illness. So how close are we to pinpointing the biological markers of mental illness, and what does that mean for diagnosis? It’s complicated. 

Host Flora Lichtman untangles some of this science with psychiatry researcher John Krystal.


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Segment Guests

John Krystal

Dr. John Krystal is a professor of psychiatry, neuroscience, and psychology at the Yale School of Medicine.

Segment Transcript

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Meet the Producers and Host

About Flora Lichtman

Flora Lichtman is a host of Science Friday. In a previous life, she lived on a research ship where apertivi were served on the top deck, hoisted there via pulley by the ship’s chef.

About Shoshannah Buxbaum

Shoshannah Buxbaum is a producer for Science Friday. She’s particularly drawn to stories about health, psychology, and the environment. She’s a proud New Jersey native and will happily share her opinions on why the state is deserving of a little more love.

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