10/02/2025

What Do We Know About SSRI Antidepressant Withdrawal?

Roughly 1 in 10 Americans take antidepressants. The most common type is SSRIs, or selective serotonin re-uptake inhibitors, like Prozac, Lexapro, and Zoloft. But what happens when you stop taking them? Studies don’t point to a single conclusion, and there’s ongoing debate among physicians and patients about the severity and significance of SSRI withdrawal symptoms. The discourse reached a fever pitch when Health Secretary Robert F. Kennedy Jr. compared SSRI withdrawal to heroin withdrawal in January.

Host Flora Lichtman digs into the data on SSRI withdrawal with psychiatrists Awais Aftab and Mark Horowitz.


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Segment Guests

Awais Aftab

Dr. Awais Aftab is a clinical associate professor of psychiatry at Case Western Reserve University.

Mark Horowitz

Dr. Mark Horowitz is a clinical research fellow in the UK’s National Health Service and  scientific co-founder of Outro Health.

Segment Transcript

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Meet the Producers and Host

About Shoshannah Buxbaum

Shoshannah Buxbaum is a producer for Science Friday. She’s particularly drawn to stories about health, psychology, and the environment. She’s a proud New Jersey native and will happily share her opinions on why the state is deserving of a little more love.

About Flora Lichtman

Flora Lichtman is a host of Science Friday. In a previous life, she lived on a research ship where apertivi were served on the top deck, hoisted there via pulley by the ship’s chef.

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